Patch-to-Global: Random Patch Diffusion for Globally Consistent Megapixel Artifact Inpainting in Whole Slide Images
为解决全切片图像中的组织伪影问题,提出RestorePath框架,通过结合潜扩散模型、病理基础模型嵌入及大核注意力机制等方法,在百万像素尺度上实现全局一致的修复。
为解决全切片图像中的组织伪影问题,提出RestorePath框架,通过结合潜扩散模型、病理基础模型嵌入及大核注意力机制等方法,在百万像素尺度上实现全局一致的修复。
本文通过结合零样本和LoRA调整模型的方法,解决了细粒度幻觉检测问题,并在SHROOM-Visions 2026竞赛中验证了其有效性。
This work proposes Federated Inference (FI) as a complementary paradigm to federated learning, enabling secure collaboration among private models during inference without sharing data or model parameters. The study introduces the first unified abstraction framework for FI, articulating two core objectives: preserving privacy during inference and achieving performance gains through collaboration. Building upon secure multi-party computation, the authors design a privacy-preserving collaborative inference architecture that integrates ensemble learning and incentive mechanisms. Systematic modeling and empirical analysis are conducted under non-IID data distributions and stringent privacy constraints. Experimental results reveal critical trade-offs among privacy, collaboration efficacy, and incentive alignment, underscoring the necessity of designing FI systems independently from conventional training-centric paradigms.
This work addresses the challenge of leveraging functional group–based causal priors and identifying critical substructures in few-shot molecular property prediction. To this end, we propose CaMol, a novel framework that introduces causal inference into this task for the first time. By constructing a contextual graph that integrates functional groups, molecular structures, and target properties, and combining it with a learnable atomic masking strategy and a chemistry-informed backdoor adjustment mechanism, CaMol effectively disentangles causal effects from confounding factors to identify substructures directly causally linked to the target property. Extensive experiments demonstrate that CaMol significantly improves both prediction accuracy and sample efficiency across multiple datasets. Moreover, the identified causal substructures show strong alignment with known functional groups, highlighting the model’s high performance and interpretability.
Existing molecular graph pretraining struggles to simultaneously ensure cross-view (2D/3D) semantic consistency and alignment of functionally critical substructures. To address this, we propose the Multi-View Conditional Information Bottleneck (MVCIB) framework, which achieves fine-grained cross-view alignment via context-guided representation learning and a functional-group-driven substructure anchoring mechanism. MVCIB is the first method to attain geometric discriminability at the 3D Weisfeiler–Lehman hierarchy level. It integrates ego-network modeling with cross-view attention to jointly optimize 2D topological and 3D geometric representations. Evaluated on four molecular property prediction benchmarks, MVCIB significantly outperforms state-of-the-art methods—particularly excelling at distinguishing stereoisomers with identical 2D graphs but distinct 3D conformations. The framework delivers both superior predictive performance and enhanced interpretability through principled substructure grounding.
为解决全切片图像中的组织伪影问题,提出RestorePath框架,通过结合潜扩散模型、病理基础模型嵌入及大核注意力机制等方法,在百万像素尺度上实现全局一致的修复。
本文通过结合零样本和LoRA调整模型的方法,解决了细粒度幻觉检测问题,并在SHROOM-Visions 2026竞赛中验证了其有效性。
This work proposes Federated Inference (FI) as a complementary paradigm to federated learning, enabling secure collaboration among private models during inference without sharing data or model parameters. The study introduces the first unified abstraction framework for FI, articulating two core objectives: preserving privacy during inference and achieving performance gains through collaboration. Building upon secure multi-party computation, the authors design a privacy-preserving collaborative inference architecture that integrates ensemble learning and incentive mechanisms. Systematic modeling and empirical analysis are conducted under non-IID data distributions and stringent privacy constraints. Experimental results reveal critical trade-offs among privacy, collaboration efficacy, and incentive alignment, underscoring the necessity of designing FI systems independently from conventional training-centric paradigms.
This work addresses the challenge of leveraging functional group–based causal priors and identifying critical substructures in few-shot molecular property prediction. To this end, we propose CaMol, a novel framework that introduces causal inference into this task for the first time. By constructing a contextual graph that integrates functional groups, molecular structures, and target properties, and combining it with a learnable atomic masking strategy and a chemistry-informed backdoor adjustment mechanism, CaMol effectively disentangles causal effects from confounding factors to identify substructures directly causally linked to the target property. Extensive experiments demonstrate that CaMol significantly improves both prediction accuracy and sample efficiency across multiple datasets. Moreover, the identified causal substructures show strong alignment with known functional groups, highlighting the model’s high performance and interpretability.
Existing molecular graph pretraining struggles to simultaneously ensure cross-view (2D/3D) semantic consistency and alignment of functionally critical substructures. To address this, we propose the Multi-View Conditional Information Bottleneck (MVCIB) framework, which achieves fine-grained cross-view alignment via context-guided representation learning and a functional-group-driven substructure anchoring mechanism. MVCIB is the first method to attain geometric discriminability at the 3D Weisfeiler–Lehman hierarchy level. It integrates ego-network modeling with cross-view attention to jointly optimize 2D topological and 3D geometric representations. Evaluated on four molecular property prediction benchmarks, MVCIB significantly outperforms state-of-the-art methods—particularly excelling at distinguishing stereoisomers with identical 2D graphs but distinct 3D conformations. The framework delivers both superior predictive performance and enhanced interpretability through principled substructure grounding.