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University Medical Center Hamburg-Eppendorf

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Research library7linked papers
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Selected work

Representative Papers

Layer Selection in Feature-Based Losses Affects Image Quality and Microstructural Consistency in Deep Learning Super-Resolution of Brain Diffusion MRI

May 15, 2026

This study addresses the challenges of high-resolution diffusion MRI, which is constrained by hardware limitations and prolonged scan times. Existing deep learning–based super-resolution methods often introduce artifacts and compromise microstructural consistency. Leveraging 7T human connectome data, the authors employ a UNet architecture for 2D super-resolution reconstruction and systematically evaluate the impact of feature loss derived from different layers of VGG16 on image fidelity and diffusion signal consistency. They find, for the first time, that deeper-layer feature losses induce grid-like artifacts and bias diffusion parameter estimation, whereas the shallowest-layer feature loss best preserves microstructural integrity. Experiments demonstrate that this strategy effectively suppresses artifacts even at up to 9× super-resolution, yielding reconstructions highly consistent with ground-truth high-resolution data, with both image signal-to-noise ratio and VGG layer depth jointly modulating artifact manifestation.

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Recent publications

Latest Papers

Layer Selection in Feature-Based Losses Affects Image Quality and Microstructural Consistency in Deep Learning Super-Resolution of Brain Diffusion MRI

May 15, 2026

This study addresses the challenges of high-resolution diffusion MRI, which is constrained by hardware limitations and prolonged scan times. Existing deep learning–based super-resolution methods often introduce artifacts and compromise microstructural consistency. Leveraging 7T human connectome data, the authors employ a UNet architecture for 2D super-resolution reconstruction and systematically evaluate the impact of feature loss derived from different layers of VGG16 on image fidelity and diffusion signal consistency. They find, for the first time, that deeper-layer feature losses induce grid-like artifacts and bias diffusion parameter estimation, whereas the shallowest-layer feature loss best preserves microstructural integrity. Experiments demonstrate that this strategy effectively suppresses artifacts even at up to 9× super-resolution, yielding reconstructions highly consistent with ground-truth high-resolution data, with both image signal-to-noise ratio and VGG layer depth jointly modulating artifact manifestation.

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