Evolutionarily Stable Stackelberg Equilibrium
This study addresses the challenge posed by mutant invasions to equilibrium stability in leader–follower games by proposing the evolutionarily stable Stackelberg equilibrium (SESS). In this framework, the leader commits to a mixed strategy while anticipating that a symmetric population of followers will adopt an evolutionarily stable strategy (ESS) in the subgame, subject to ecological constraints. This work is the first to explicitly incorporate evolutionary stability into the Stackelberg setting, distinguishing between the ESS choices of leaders and followers and thereby overcoming a key limitation of existing approaches that neglect resistance to mutations. Integrating game theory, ESS theory, and optimization algorithms, the authors develop an efficient computational method for SESS applicable to both discrete and continuous games, demonstrating its efficacy in biological contexts such as cancer therapy—where the physician acts as the leader and cancer cell phenotypes constitute the follower population.