Towards clinical adoption of voice and speech as measures of health: the need for harmonization
This study addresses the limited reproducibility of vocal biomarkers caused by heterogeneous data and processing pipelines, which severely impedes their clinical translation. By systematically reviewing the full lifecycle of voice-based health measurement, this work proposes a standardization pathway anchored in unified acoustic metric definitions. Specifically, it establishes a minimal core metric set encompassing respiratory and phonatory dimensions with clearly defined physiological mappings, while integrating acoustic feature computation, machine learning modeling, and clinical interpretation into a cohesive framework. The research provides reproducible metric definitions alongside practical implementation schemes, thereby laying a foundational framework for the standardization and clinical deployment of digital vocal biomarkers.