Intervention Granularity Matters: Coherent Treatment Bundles in Counterfactual Simulation with Clinical World Models

2026-09-18

AI Summary

研究探讨了临床世界模型中干预粒度对反事实模拟的影响，通过比较单个设置与完整配置的编辑，发现干预粒度显著影响模型响应。

Abstract

Counterfactual simulation with a clinical world model means fixing a patient's history, changing the treatment, and reading off the predicted response. Doing so requires deciding what counts as one intervention. In clinical settings, interventions are documented as bundles: a co-occurrence audit of 945,707 patient-hours from MIMIC-IV shows groups of components, such as every parameter of a dialysis circuit, that never appear apart, so an edit that changes one component on its own describes an hour that never occurs in the data. We hypothesize that the granularity at which an intervention is edited changes how a world model responds, and test this with Clin-JEPA, a latent world model of patient trajectories conditioned on hourly treatment text. At 1,019 documented onsets of invasive ventilation, we keep the patient's history and other treatments fixed and compare editing one ventilator setting with editing the complete configuration recorded for a real patient with the most similar recent trajectory. The complete bundle moves the predicted next state further than any single setting, consistently across all five settings, and the difference remains after accounting for how much each edit changes the model's input. Intervention granularity therefore materially affects the response of a clinical world model: single-component edits may understate treatment sensitivity, and bundle-aware editing may offer a better-supported basis for counterfactual treatment simulation.

Problem

• intervention granularity
• counterfactual simulation
• clinical world model
• treatment bundles

Innovation

• intervention granularity
• treatment bundles
• counterfactual simulation
• clinical world model