Uniform inference in linear mixed models

📅 2025-07-25
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🤖 AI Summary
In linear mixed models, conventional asymptotic inference fails when the random-effects covariance matrix approaches or lies on the parameter boundary—e.g., zero variances or correlation coefficients tending to ±1. To address this, we propose a unified, finite-sample distributional approximation method. Our approach quantifies the deviation between linear combinations of score functions and standard normality, integrating uniform approximation theory with high-dimensional statistical techniques to construct computationally tractable confidence regions. The method accommodates both cluster-independent and crossed random-effects structures and is valid under high-dimensional asymptotics—where the number of parameters grows jointly with the number of random effects. We establish theoretical guarantees: the resulting confidence regions achieve near-nominal coverage in finite samples and remain robust under boundary scenarios. Extensive simulations confirm superior small-sample performance and computational feasibility.

Technology Category

Machine Learning: Calibration & Uncertainty QuantificationConstraint Satisfaction and Optimization: Mixed Discrete/Continuous OptimizationReasoning under Uncertainty: Relational Probabilistic Models

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📝 Abstract
We provide finite-sample distribution approximations, that are uniform in the parameter, for inference in linear mixed models. Focus is on variances and covariances of random effects in cases where existing theory fails because their covariance matrix is nearly or exactly singular, and hence near or at the boundary of the parameter set. Quantitative bounds on the differences between the standard normal density and those of linear combinations of the score function enable, for example, the assessment of sufficient sample size. The bounds also lead to useful asymptotic theory in settings where both the number of parameters and the number of random effects grow with the sample size. We consider models with independent clusters and ones with a possibly diverging number of crossed random effects, which are notoriously complicated. Simulations indicate the theory leads to practically relevant methods. In particular, the studied confidence regions, which are straightforward to implement, have near-nominal coverage in finite samples even when some random effects have variances near or equal to zero, or correlations near or equal to $pm 1$.
Problem

Research questions and friction points this paper is trying to address.

Develop uniform parameter approximations for linear mixed models
Address singular covariance matrices in random effects inference
Provide finite-sample bounds for near-boundary variance cases
Innovation

Methods, ideas, or system contributions that make the work stand out.

Finite-sample uniform distribution approximations
Bounds for singular covariance matrices
Confidence regions for near-boundary parameters
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K
Karl Oskar Ekvall
Department of Statistics, University of Florida
M
Matteo Bottai
Division of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet