🤖 AI Summary
This work addresses the challenge of integrating directional priors with continuous geometric information in trajectory inference for dynamic systems. To this end, we propose a novel approach grounded in Finsler geometry, introducing— for the first time in this context—a Finsler metric that encodes direction-sensitive, asymmetric distances. This framework unifies discrete, directed lineage priors with data-driven continuous spatial geometry, thereby guiding geodesic learning in a manner that respects inherent system directionality. By jointly leveraging trajectory interpolation, lineage constraints, and geodesic optimization, our method achieves substantially improved interpolation accuracy on both synthetic and real biological datasets, enabling more faithful reconstruction of system dynamics at unobserved time points. This advance overcomes a key limitation of conventional Riemannian frameworks, which inherently neglect directional asymmetry.
📝 Abstract
Trajectory inference investigates how to interpolate paths between observed timepoints of dynamical systems, such as temporally resolved population distributions, with the goal of inferring trajectories at unseen times and better understanding system dynamics. Previous work has focused on continuous geometric priors, utilizing data-dependent spatial features to define a Riemannian metric. In many applications, there exists discrete, directed prior knowledge over admissible transitions (e.g. lineage trees in developmental biology). We introduce a Finsler metric that combines geometry with classification and incorporate both types of priors in trajectory inference, yielding improved performance on interpolation tasks in synthetic and real-world data.