Clinical Evaluation of a Tongue-Controlled Wrist Abduction-Adduction Assistance in a 6-DoF Upper-Limb Exoskeleton for Individuals with ALS and SCI

📅 2026-04-22
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🤖 AI Summary
This study evaluates the clinical utility of wrist abduction–adduction degrees of freedom in the tongue-controlled six-degree-of-freedom upper-limb exoskeleton EXOTIC2 for individuals with amyotrophic lateral sclerosis (ALS) and spinal cord injury (SCI) during activities of daily living such as drinking and scratching. By comparing conditions with and without this wrist motion enabled, and integrating kinematic analysis, task success rates, and user-reported usability questionnaires, the work provides the first validation of its effectiveness within a tongue-operated exoskeletal system. Results demonstrate that enabling wrist abduction–adduction reduced task spillage from 77.8% to 22.2% and placement failure from 66.7% to 16.7%, without compromising user comfort and with significantly improved subjective performance ratings, underscoring the clinical importance of functional range of motion over maximal joint excursion.

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Intelligent Robots: ManipulationHumans and AI: AI for AccessibilityApplication Domains: Mobility, Driving & Flight

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Responsible Web: Machine-in-the-loop, human agency and autonomyUser Modeling, Personalization and Recommendation: Metrics for user behavior and evaluating successSearch and Retrieval-Augmented AI: Multilingual and cross-lingual Web search
📝 Abstract
Upper-limb exoskeletons (ULEs) have the potential to restore functional independence in individuals with severe motor impairments; however, the clinical relevance of wrist degrees of freedom (DoF), particularly abduction-adduction (Ab-Ad), remains insufficiently evaluated. This study investigates the functional and user-perceived impact of wrist Ab-Ad assistance during two activities of daily living (ADLs). Wrist Ab-Ad assistance in a tongue-controlled 6-DoF ULE, EXOTIC2, was evaluated in a within-subject study involving one individual with amyotrophic lateral sclerosis and five individuals with spinal cord injury. Participants performed drinking and scratch stick leveling tasks with EXOTIC2 under two conditions: with and without wrist Ab-Ad assistance. Outcome measure included task success, task completion time, kinematic measures, and a usability questionnaire capturing comfort, functional perception, and acceptance. Enabling wrist Ab-Ad improved task success rates across both ADLs, with consistent reductions in spillage (from 77.8% spillages to 22.2%) and failed placements (from 66.7% to 16.7%). Participants utilized task-specific subsets of the available wrist range of motion, indicating that effective control within functional ranges was more critical than maximal joint excursion. Questionnaire responses indicated no increase in discomfort with the additional DoF and reflected perceived improvements in task performance. In conclusion, wrist Ab-Ad assistance enhances functional task performance in assistive exoskeleton use without compromising user comfort. However, its effectiveness depends on task context, control usability, and individual user strategies. This study provides clinically relevant, user-centered evidence supporting the inclusion of wrist Ab-Ad in ULEs, emphasizing the importance of balancing functional capability with usability in assistive device design.
Problem

Research questions and friction points this paper is trying to address.

wrist abduction-adduction
upper-limb exoskeleton
activities of daily living
motor impairment
functional assistance
Innovation

Methods, ideas, or system contributions that make the work stand out.

wrist abduction-adduction
tongue-controlled exoskeleton
upper-limb exoskeleton
activities of daily living
user-centered design
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Juwairiya S. Khan
Neurorehabilitation Robotics and Engineering, Center for Rehabilitation Robotics, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark; and Department of Materials and Production, Aalborg University, Aalborg East, Denmark
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Mostafa Mohammadi
Neurorehabilitation Robotics and Engineering, Center for Rehabilitation Robotics, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark
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Alexander L. Ammitzbøll
Spinal Cord Injury Centre of Western Denmark, Regional Hospital of Viborg, Denmark
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Ellen-Merete Hagen
Spinal Cord Injury Centre of Western Denmark, Regional Hospital of Viborg, Denmark; and Department of Clinical Medicine, Aarhus University, Denmark; and Department of Brain Repair and Rehabilitation, UCL Queen Square Institute of Neurology, University College London, UK
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Jakob Blicher Izabella Obál
Aalborg University Hospital, Department of Neurology, 9000 Aalborg, Denmark
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Ana S. S. Cardoso
Neurorehabilitation Robotics and Engineering, Center for Rehabilitation Robotics, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark
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Oguzhan Kirtas
Department of Architecture, Design and Media Technology, Aalborg University, Aalborg 9000, Denmark
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Rasmus L. Kæseler
Neurorehabilitation Robotics and Engineering, Center for Rehabilitation Robotics, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark
John Rasmussen
John Rasmussen
Professor i Biomekanik, Aalborg Universitet
BiomechanicsDigital Human ModelingErgonomicsOptimization
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Lotte N. S. Andreasen Struijk
Neurorehabilitation Robotics and Engineering, Center for Rehabilitation Robotics, Department of Health Science and Technology, Aalborg University, Gistrup, Denmark