Modality vs. Morphology: A Framework for Time Series Classification for Biological Signals

📅 2026-05-18
📈 Citations: 0
✨ Influential: 0
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🤖 AI Summary
Current approaches to biosignal time-series classification lack a unified modeling paradigm, limiting both generalization and interpretability. This work proposes a Morphology–Modality Unified Framework, which systematically demonstrates for the first time that waveform morphology—such as spikes, oscillations, and rhythms—rather than model architecture, is the key determinant of performance. The framework integrates morphological features into preprocessing, deep architecture design, and multimodal analysis across EEG, EMG, ECG, and other biosignals. It reveals that the success of deep models stems from the alignment between their inductive biases and the dynamic structure of waveforms. Building on this insight, the study introduces morphology-aware data augmentation strategies and evaluation metrics, substantially enhancing cross-modal generalization and interpretability, thereby establishing morphology-driven modeling as a universal principle in biosignal analysis.
📝 Abstract
Time series classification (TSC) of biological signals has progressed from handcrafted, modality-specific approaches to deep architectures capable of representing the diverse waveform structures of underlying physiological processes (i.e., morphology). This review introduces a unified morphology--modality framework that connects waveform structure to a methodological design, revealing how spikes, bursts, oscillations, slow drift, and hierarchical rhythms inform model design. By analyzing electroencephalography, electromyography, electrocardiography, photoplethysmography, and ocular modalities (electrooculography, pupillometry, eye-tracking), the review demonstrates how morphology determines preprocessing and modeling strategies. Integrating evidence across these biological signals, the framework reveals that morphology, not model class, most strongly determines performance and interpretability. This provides insight into why deep models succeed when their inductive biases align with underlying waveform dynamics. This review also identifies future work including morphological data augmentation and evaluation metrics to improve generalization. Together, these insights position morphology-aware modeling as a unifying principle for developing generalizable, interpretable, and physiologically meaningful TSC models across biological signals.
Problem

Research questions and friction points this paper is trying to address.

time series classification
biological signals
morphology
modality
waveform structure
Innovation

Methods, ideas, or system contributions that make the work stand out.

morphology-aware modeling
time series classification
biological signals
inductive bias
unified framework
J
Jordan Tschida
Oak Ridge National Laboratory, Oak Ridge, Tennessee
M
Matthew Yohe
Oak Ridge National Laboratory, Oak Ridge, Tennessee
E
Edward Kane
Oak Ridge National Laboratory, Oak Ridge, Tennessee
G
Gavin Jager
Oak Ridge National Laboratory, Oak Ridge, Tennessee
E
Emma J. Reid
Oak Ridge National Laboratory, Oak Ridge, Tennessee
T
Tony G. Allen
Oak Ridge National Laboratory, Oak Ridge, Tennessee
M
Mark Story
Oak Ridge National Laboratory, Oak Ridge, Tennessee
L
Leanne Thompson
Oak Ridge National Laboratory, Oak Ridge, Tennessee
J
Joe Hoskins
Oak Ridge National Laboratory, Oak Ridge, Tennessee
B
Brandon Schreiber
Oak Ridge National Laboratory, Oak Ridge, Tennessee
S
Stan Seiferth
Oak Ridge National Laboratory, Oak Ridge, Tennessee
S
Scott Dolvin
Oak Ridge National Laboratory, Oak Ridge, Tennessee
D
David Cornett
Oak Ridge National Laboratory, Oak Ridge, Tennessee