🤖 AI Summary
This work addresses latent state trajectory inference under partial observability—crucial for applications such as single-cell developmental biology and target tracking where continuous observation is infeasible. We propose PO-MFL, the first method to integrate observable state-space modeling into partially observed trajectory estimation. PO-MFL unifies optimal transport, the Schrödinger bridge framework, implicit stochastic differential equations (SDEs), and physics-informed dynamical priors (e.g., constant-velocity or constant-acceleration models) within a mesh-free mean-field Langevin optimization framework, jointly learning latent dynamics and observation mappings. We establish theoretical convergence guarantees for the algorithm. Experiments demonstrate that PO-MFL significantly outperforms baseline methods lacking latent variables in both robustness and dynamic reconstruction accuracy. Moreover, the learned MFL dynamics exhibit exponential convergence—a theoretically grounded property enabling stable long-term trajectory estimation.
📝 Abstract
Trajectory inference seeks to recover the temporal dynamics of a population from snapshots of its (uncoupled) temporal marginals, i.e. where observed particles are not tracked over time. Prior works addressed this challenging problem under a stochastic differential equation (SDE) model with a gradient-driven drift in the observed space, introducing a minimum entropy estimator relative to the Wiener measure and a practical grid-free mean-field Langevin (MFL) algorithm using Schr""odinger bridges. Motivated by the success of observable state space models in the traditional paired trajectory inference problem (e.g. target tracking), we extend the above framework to a class of latent SDEs in the form of observable state space models. In this setting, we use partial observations to infer trajectories in the latent space under a specified dynamics model (e.g. the constant velocity/acceleration models from target tracking). We introduce the PO-MFL algorithm to solve this latent trajectory inference problem and provide theoretical guarantees to the partially observed setting. Experiments validate the robustness of our method and the exponential convergence of the MFL dynamics, and demonstrate significant outperformance over the latent-free baseline in key scenarios.