ExpertoRhythm: Morphology-Aware Learning for Waveform Reconstruction and Cuffless Blood Pressure Estimation from Single-Channel PPG

📅 2026-09-28
🏛️ Conference on Artificial Intelligence in Medicine in Europe
📈 Citations: 0
✨ Influential: 0
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🤖 AI Summary
This study addresses the challenge of preserving waveform morphology and dynamic variations when estimating blood pressure from single-channel photoplethysmography (PPG). We propose a cuffless continuous blood pressure monitoring method based on an attention-enhanced 1D U-Net. By designing a composite morphology-aware objective function that combines range-weighted SmoothL1 loss with window-based regularization, the approach amplifies high-dynamic segment features while suppressing amplitude errors, enabling precise PPG-to-arterial blood pressure waveform reconstruction and direct systolic/diastolic blood pressure (SBP/DBP) estimation. Experimental results demonstrate mean absolute errors of 2.46 mmHg for SBP and 1.46 mmHg for DBP, achieving a 30.4% relative error reduction over the MSE baseline and satisfying both AAMI and BHS Grade A clinical standards.
📝 Abstract
Continuous cuffless blood pressure (BP) monitoring from photoplethysmography (PPG) has strong potential for wearable health and telemonitoring, but accurate estimation remains difficult because PPG-to-BP mapping must preserve subtle waveform morphology and pressure-range-dependent dynamics. We introduce ExpertoRhythm, an attention-enhanced 1D U-Net that reconstructs the arterial blood pressure (ABP) waveform from a single-channel PPG signal and derives systolic and diastolic BP directly from the reconstructed waveform. The central contribution is a composite morphology-aware learning objective that integrates range-weighted SmoothL1 reconstruction with a window-range regularizer to emphasize high-dynamic BP segments and reduce amplitude under/over-shoot. On the UCI cuff-less BP dataset with 942 subjects, ExpertoRhythm achieves 2.46/1.46 mmHg MAE for systolic/diastolic BP (SBP/DBP), while obtaining a 30.4% average relative error reduction over pure MSE across waveform reconstruction and BP estimation metrics. Clinical-style evaluation further demonstrates low bias and strong agreement across the BP range, including high-pressure windows up to 200 mmHg, satisfying AAMI criteria and achieving BHS Grade A. These results suggest that morphology-aware waveform reconstruction from a single PPG channel can provide an accurate and practical pathway toward continuous cuffless BP monitoring in wearable and remote-care settings.
Problem

Research questions and friction points this paper is trying to address.

Cuffless Blood Pressure Estimation
Photoplethysmography (PPG)
Waveform Reconstruction
Wearable Health Monitoring
Innovation

Methods, ideas, or system contributions that make the work stand out.

Morphology-Aware Learning
1D U-Net
Cuffless Blood Pressure Estimation
Waveform Reconstruction
Photoplethysmography
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