DefTransNet: A Transformer-based Method for Non-Rigid Point Cloud Registration in the Simulation of Soft Tissue Deformation

📅 2025-02-10
📈 Citations: 0
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🤖 AI Summary
Non-rigid registration of soft-tissue point clouds remains challenging due to large deformations, sensor noise, partial overlap, and outliers—leading to poor robustness and low correspondence accuracy. To address this, we propose an end-to-end Transformer-based architecture that directly regresses a dense displacement field from source to target point clouds. Our key contributions are: (1) a learnable affine transformation module to improve initial alignment robustness; (2) a multi-scale geometric feature encoder that jointly captures global context and local structural details; and (3) a Transformer backbone to model long-range point-wise dependencies, thereby enhancing modeling capacity for complex, non-linear deformations. Extensive experiments on four benchmarks—ModelNet, SynBench, 4DMatch, and DeformedTissue—demonstrate consistent state-of-the-art performance, with significant gains in both registration accuracy and cross-domain generalization.

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📝 Abstract
Soft-tissue surgeries, such as tumor resections, are complicated by tissue deformations that can obscure the accurate location and shape of tissues. By representing tissue surfaces as point clouds and applying non-rigid point cloud registration (PCR) methods, surgeons can better understand tissue deformations before, during, and after surgery. Existing non-rigid PCR methods, such as feature-based approaches, struggle with robustness against challenges like noise, outliers, partial data, and large deformations, making accurate point correspondence difficult. Although learning-based PCR methods, particularly Transformer-based approaches, have recently shown promise due to their attention mechanisms for capturing interactions, their robustness remains limited in challenging scenarios. In this paper, we present DefTransNet, a novel end-to-end Transformer-based architecture for non-rigid PCR. DefTransNet is designed to address the key challenges of deformable registration, including large deformations, outliers, noise, and partial data, by inputting source and target point clouds and outputting displacement vector fields. The proposed method incorporates a learnable transformation matrix to enhance robustness to affine transformations, integrates global and local geometric information, and captures long-range dependencies among points using Transformers. We validate our approach on four datasets: ModelNet, SynBench, 4DMatch, and DeformedTissue, using both synthetic and real-world data to demonstrate the generalization of our proposed method. Experimental results demonstrate that DefTransNet outperforms current state-of-the-art registration networks across various challenging conditions. Our code and data are publicly available.
Problem

Research questions and friction points this paper is trying to address.

Handles non-rigid point cloud registration
Addresses large deformations and outliers
Improves robustness against noise and partial data
Innovation

Methods, ideas, or system contributions that make the work stand out.

Transformer-based architecture
Learnable transformation matrix
Global and local geometric integration
S
Sara Monji-Azad
Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
Marvin Kinz
Marvin Kinz
Harvard Medical School / BWH / DFCI, Heidelberg University
Medical PhysicsImage AnalysisMachine LearningImage RegistrationComputer Vision
S
Siddharth Kothari
International Institute of Information Technology, Bangalore, India
R
Robin Khanna
Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
A
Amrei Carla Mihan
Mannheim Institute for Intelligent Systems in Medicine (MIISM), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
D
David Maennel
Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; AI Health Innovation Cluster, Heidelberg-Mannheim Health and Life Science Alliance, Heidelberg, Germany
Claudia Scherl
Claudia Scherl
Unknown affiliation
Juergen Hesser
Juergen Hesser
Heidelberg University