Evaluating quality in synthetic data generation for large tabular health datasets

📅 2026-04-17
📈 Citations: 0
Influential: 0
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🤖 AI Summary
This study addresses the lack of standardized evaluation protocols in existing methods for synthesizing health tabular data. To this end, it systematically assesses the performance of seven prominent generative models across four health datasets of varying scales, employing consistent hyperparameter tuning and joint distribution fidelity metrics to ensure a fair comparison. The work introduces a novel, unified evaluation framework that integrates multidimensional quantitative metrics with visual analytics, complemented by domain-informed medical interpretation. Through this approach, the study uncovers critical limitations of current models in adhering to clinical constraints and provides a reproducible, interpretable foundation for selecting appropriate synthetic data generators in healthcare applications.

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📝 Abstract
There is no consensus in the field of synthetic data on concise metrics for quality evaluations or benchmarks on large health datasets, such as historical epidemiological data. This study presents an evaluation of seven recent models from major machine learning families. The models were evaluated using four different datasets, each with a distinct scale. To ensure a fair comparison, we systematically tuned the hyperparameters of each model for each dataset. We propose a methodology for evaluating the fidelity of synthesized joint distributions, aligning metrics with visualization on a single plot. This method is applicable to any dataset and is complemented by a domain-specific analysis of the German Cancer Registries' epidemiological dataset. The analysis reveals the challenges models face in strictly adhering to the medical domain. We hope this approach will serve as a foundational framework for guiding the selection of synthesizers and remain accessible to all stakeholders involved in releasing synthetic datasets.
Problem

Research questions and friction points this paper is trying to address.

synthetic data
quality evaluation
health datasets
benchmarking
tabular data
Innovation

Methods, ideas, or system contributions that make the work stand out.

synthetic data evaluation
tabular health data
joint distribution fidelity
hyperparameter tuning
domain-specific benchmarking
J
Jean-Baptiste Escudié
Centre for Artificial Intelligence in Public Health Research, Robert Koch Institute; German Centre for Cancer Registry Data, Robert Koch Institute; Medical Informatics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin
B
Benjamin Barnes
German Centre for Cancer Registry Data, Robert Koch Institute
S
Stefan Meisegeier
German Centre for Cancer Registry Data, Robert Koch Institute
K
Klaus Kraywinkel
German Centre for Cancer Registry Data, Robert Koch Institute
Fabian Prasser
Fabian Prasser
Berlin Institute of Health @ Charité - Universitätsmedizin Berlin
Medical InformaticsInformation IntegrationData Privacy
N
Nils Körber
Centre for Artificial Intelligence in Public Health Research, Robert Koch Institute