Scholar
Patrick D. Hsu
Google Scholar ID: LhnU_joAAAAJ
Arc Institute | University of California, Berkeley
Citations & Impact
Citations
37,968
H-index
40
i10-index
65
Publications
20
Co-authors
5
list available
Contact
Publications
Resume (English only)
Academic Achievements
- Published papers: 'Virtual Cell Challenge: Toward a Turing test for the virtual cell', 'Predicting cellular responses to perturbation across diverse contexts with STATE', 'Megabase-scale human genome rearrangement with programmable bridge recombinases' etc.
Research Experience
- Programming biology at multiple levels, contributions include early development of CRISPR-Cas9 for human genome editing, discovery and development of CRISPR-Cas13d for transcriptome engineering, and developing various classes of recombinases for large-scale DNA rearrangement and genome design; applying these tools to manipulate higher levels of biological organization at tissue and physiological levels; pushing the boundaries of synthetic biology, particularly in cell type-specific control of biological perturbations, tuning epigenetic memory, and manipulating RNA splicing; exploring the potential to simulate a virtual cell by integrating machine learning with large genomic datasets.
Background
- Research interests include biological programming, synthetic biology, and the integration of biology and AI. Specializes in gene editing tools (like CRISPR-Cas9 and Cas13d) and recombinase development.
